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Posts Tagged ‘biological synthesis’

The explanation may very well emerge from understanding that the skin matrix is responsible for the skin’s mechanical properties, like firmness, strength, suppleness, and elasticity. Stretch marks are tears in a skin matrix affected by atrophy, a condition characterized by exactly the opposite of those just described. Yes, skin affected by pregnancy stretch marks is identified by thinning, weakness, roughness, sagging, stiffness and decrease in the size of tissues, diminished cellular proliferation, and loss of function, also called atrophia.

The skin matrix is a valued resource which is both produced and consumed quite frequently during our lives. On one side, skin matrix is regularly synthesized by fibroblasts. On the other side, whenever it is damaged, malformed or worn out, skin matrix – especially the structural proteins collagen and elastin- is broken down into particles by collagenase and gelatinase enzymes, also named matrix metalloproteinases (MMP) and then recycled. By digesting key matrix proteins, such as collagen and elastin, MMP enzymes play an underappreciated yet critical function in skin physiology.

In healthy or youthful skin, the degradation and biological synthesis of the matrix are in balance: damaged or disfunctional matrix is degraded while the deficit is replenished by the progressing biosynthesis. Unfortunately, this difficult balance gets interrupted because of hormonal imbalances, malnutrition, or and as we age, too little of the matrix is synthesized and too much is degraded. As with any supply-demand imbalance, it can be bettered by either increasing supply (boosting biosynthesis of the matrix) or reducing demand (inhibiting the breakdown).

In particular, the synthesis of elastin is physiologically essential, although elastin is only 2% of the total protein in the dermis. These skin fibers provide the resiliency of skin.

Elastin synthesis and the regulation of the quantity of cross-linked insoluble collagen and elastin fibers depends on the interaction between 3 factors. The first is the presence of active fibroblasts, which secrete the soluble precursor of elastin, tropoelastin. The second is the relative amount of several skin matrix components within the dermis also exuded by fibroblasts. The third are enzymes that are in charge of both cell degradation processes that allows the breakdown of dead cells into their component amino acids and their re-use for the synthesis of new proteins (amino-acid chains).

So beware of pregnancy stretch mark products that contain soluble collagen and/or elastin, they will NOT do the trick.

What is needed is the biosynthesis and appropriate self-assembly of complex skin structures from inside out your body. The first step in elastic fiber formation is the manifestation of small cell surface-associated elastin globules (soluble tropoelastin) that augment in size with time (microassembly). The elastin globules are eventually transferred to pre-existing elastic fibers in the extracellular matrix where, through an intricate and coordinated biological process, they integrate into bigger structures (macroassembly) and become crosslinked funtional fiber-like polymers with changeable deformation and high resilience.

Collagen and Elastin Synthesis Boosters May Fail or Fall Short in People Affected by Atrophic Skin.

The most recent pregnancy stretch mark treatments and prevention products are aimed at restoring skin matrix by stimulating the synthesis of collagen or elastin (e.g. ascorbic acid, copper peptides, palmitoyl pentapeptide, oligopeptides and other|synthetic copper peptides, ascorbic acid, oligopeptides, palmitoyl pentapeptide, and other). Unfortunately, this mode fails or falls short in most people affected by atrophic skin, presumably due to the particular chemistry of skin affected by such condition and an incapacity to respond to matrix synthesis boosters.

Their failure to treat existing pregnancy stretch marks is most probably due to something important ingredient missing in those products; an element that would help your skin to get rid of scar tissues . In fact, your body needs two things to perform this.

One, your body needs to be able to distinguish or identify scar tissue from the adjacent functional tissues in the skin matrix. Second, it must be able to degrade the proteins that those scars are made off and divide their component amino-acids to then eventually use them to generate new skin matrix components.

This can only be achieved by the action of two types of ingredients that act together.

One is messenger molecules that are able to link communication between cells and allow them to differentiate scars from functional and/ or healthy tissues and trigger fibroblast proliferation. The other crucial ingredient is enzymes that dissolve the non functional, worn out, or damaged tissues that were recognized by the messenger molecules.

Combined methods that introduce some form of abrading to physically break down some of the more superficial scarring, and a topical stretch mark product that includes not just moisturizer enhancers or collagen synthesis boosters, but also cell communicating ingredients, enzymes that ‘dissolve’ damaged cells and scar proteins and skin regenerating activators can yield substantial improvements.

Such stretch mark product can also effectively prevent stretch marks.